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논문분류	춘계학술대회 초록집
제목	Occult Hepatitis B virus Infection of Haemodialysis Patients: A Case-control Study in A Hepatitis B Virus-endemic Region
저자	So Mi Kim1, Hyun Woo Kim1, Miyeon Kim1, Ji Eun Lee2, Do Hyun Lee2, Eun Kyoung Lee2, Jong Tae Cho2
출판정보	2014; 2014(1):
키워드	B형간염, B형간염 바이러스 잠재감염, 혈액투석
초록	Background: Occult hepatitis B virus (HBV) infection of haemodialysis (HD) patients is informative in terms of virus transmission, reactivation after kidney transplantation, and the progression of liver disease. However, there is little detailed information about occult HBV infection in the context of virus endemicity. Patients and methods: To investigate the seroprevalence and clinical features of occult HBV infection in HD patients in HBV-endemic regions, we recruited a total of 159 HD patients at Dankook University Hospital and Jeju National University Hospital in Korea. Hepatitis B surface antigen (HBsAg), anti-HBs, anti-HBc, and anti-hepatitis C virus (HCV) antibody levels were measured by radioimmunoassay. Serum levels of HBV DNA were measured by real-time polymerase chain reaction (lowest limit of detection, 116 copies/mL). Results: The control group comprised 121 age- and gender-matched healthy HBsAg-negative individuals. The seroprevalence of occult HBV infection was 1.3 %in HD patients and 2.5 %in the healthy controls. This difference was not significant. The HBV load in all subjects with occult infection was <116 copies/mL, and all were positive for IgG anti-HBc, regardless of the presence of anti-HBs. None of the occult HBV-infected subjects were co-infected with HCV. One of the two HD patients with occult HBV infection had no history of blood transfusion. Conclusions: In this HBV-endemic region, the seroprevalence of occult HBV infection in HD patients with a very low viral load was not significantly different from that in healthy controls.
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