대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Resistance to Erythropoiesis-stimulating Agents is Associated with Arterial Micro-calcification in Early Hemodialysis Patients
저자	Su Jin Choi, Hye Sung Won, Sun Ae Yoon, Young Soo Kim, Young Ok Kim
출판정보	2014; 2014(1):
키워드	조혈제저항성, 미세석회화, 혈액투석
초록	Objectives: Anemia is a common complication in patients with chronic kidney disease because of their relative erythropoietin deficiency. Despite treatment with erythropoiesis-stimulating agents (ESAs), some patients experienced ESA hyporesponsiveness. The aim of this study was to evaluate the relationship between arterial microcalcification (AMiC) and ESA hyporesponsiveness in hemodialysis patients. Methods: 82 hemodialysis patients received with ESAs for anemia without iron deficiency were evaluated. We assessed ESA hyporesponsiveness of patients using ESA hyporesponsiveness index (EHRI), defined as the weekly ESA dose per kilogram of body weight divided by the hemoglobin level. The arterial microcalcification was diagnosed by pathologic examination of arterial specimen by von Kossa stain, which was acquired during the operation. Results: AMiC was detected in 33 (40.2%) of 82 patients. Patients with diabetes had a higher incidence of AMiC than patients without diabetes. The serum levels of albumin and cholesterol were higher in patients without AMiC than in patients with AMiC. The serum levels of intact parathyroid hormone were lower in patients with AMiC than in patients without AMiC. The serum levels of phosphate and calcium-phosphorus product did not differ between the two groups. The mean EHRI value was higher in patients with AMiC than in patients without AMiC. In multivariate analyses, ESA hyporesponsiveness and diabetes showed a significant association with AMiC. Conclusion: ESA hyporesponsiveness may be a clinical relevant parameters related to AMiC in hemodialysis patients. Further large-scaled studies are needed to validate this relevance more clearly.
원문(PDF)	PDF 원문보기

목록

위로가기