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논문분류	춘계학술대회 초록집
제목	Comparison of the Impact of High-flux Dialysis on Mortality in Hemodialysis Patients with and without Residual Renal Function
저자	Ji In Hyun1, Su-Hyun Kim2, Hyung Wook Kim1, Young Ok Kim1, Dong Chan Jin1,Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim3, Yon-Su Kim4,Shin-Wook Kang5, Nam-Ho Kim6, Chul Woo Yang1, Yong Kyun Kim1
출판정보	2014; 2014(1):
키워드	Hemodialysis, β2-microglobulin, β2-microglobulin, Hemodialysis, Mortality
초록	Background: The effect of flux membranes on mortality in hemodialysis (HD) patients is controversial. Residual renal function (RRF) has shown to not only be as a predictor of mortality but also a contributor to β2-microglobulin clearance in HD patients. Our study aimed to determine the interaction of residual renal function with dialyzer membrane flux on mortality in HD patients. Methods: HD Patients were included from the Clinical Research Center registry for End Stage Renal Disease, a prospective observational cohort study in Korea. Cox proportional hazards regression models were used to study the association between use of high-flux dialysis membranes and all-cause mortality with RRF and without RRF. The primary outcome was all-cause mortality. Results: This study included 893 patients with 24h-residual urine volume ≥ 100 mL (569 and 324 dialyzed using low-flux and high-flux dialysis membranes, respectively) and 913 patients with 24h-residual urine volume <100 mL (570 and 343 dialyzed using low-flux and high-flux dialysis membranes, respectively). After a median follow-up period of 31 months, mortality was not significantly different between the high and low-flux groups in patients with 24h-residual urine volume ≥100 mL (HR 0.86, 95% CI, 0.38-1.95, p=0.723). In patients with 24h-residual urine volume <100 mL, HD using high-flux dialysis membrane was associated with decreased mortality compared to HD using low-flux dialysis membrane in multivariate analysis (HR 0.40, 95% CI, 0.21-0.78, p=0.007). Conclusions: Our data showed that HD using high-flux dialysis membranes had a survival benefit in patients with 24h-residual urine volume <100 mL, but not in patients with 24h-residual urine volume ≥ 100 mL. These findings suggest that high-flux dialysis rather than low-flux dialysis might be considered in HD patients without RRF.
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