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논문분류	춘계학술대회 초록집
제목	Paricalcitol Ameliorates the Chlorhexidine-induced Peritoneal Fibrosis in Rats
저자	Eun Woo Choi, Seok Hui Kang, Su Jung Lee, Mun Ju Hwang, Joon Hyuk Seo,Kyu Hyang Cho, Jong Won Park, Kyung Woo Yoon, Jun Young Do
출판정보	2014; 2014(1):
키워드	페리칼시톨, 복막섬유화, 클로르헥시딘
초록	Background: The aim of this study was to evaluate the efficacy of paricalcitol on chlorhexidine gluconate-induced peritoneal fibrosis in rats. Materials and Methods: Peritoneal fibrosis was induced by intraperioneal injection of 0.1% chlrohexidine-gluconate (CG) dissolved in saline. Twenty-four male Sprague-Dawley rats weight 250-300 g were purchased from the Orient Co. Rats were divided into 3 groups. The C group received injection of normal saline. The CHX group received CG every other day for 4 weeks. The P group were received CG and cotreated with paricalcitol. At the end of 4 weeks, rats were sacrificed for morphometric and histologic analyses. Results: Macroscopic findings showed that severe inflammatory changes of peritoneum and cocoon formation were confirmed in CHX group. The paricalcitol ameliorated these peritoneal changes. The thickness of the peritoneal membrane in CHX was significantly increased compared with that of the C group. Cotreatment with paricalcitol decreased peritoneal thickness. In addition, CG decreased the protein level of the epithelial cell marker in peritoneal tissue and increased the expression levels of the mesenchymal markers. Cotreatment with paricalcitol decreased these pathologic changes. Conclusion: The present study showed that paricalcitol ameliorates the CG-induced peritoneal fibrosis in rats.
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