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논문분류	춘계학술대회 초록집
제목	Serum Gamma-glutamyltransferase Levels Predict Mortality in Peritoneal Dialysis Patients
저자	Woo Yeong Park1, Su-Hyun Kim2, Hyung Wook Kim1, Young Ok Kim1, Dong Chan Jin1,Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim3, Yon-Su Kim4, Shin-Wook Kang5,Nam-Ho Kim6, Chul Woo Yang1, Yong Kyun Kim1
출판정보	2014; 2014(1):
키워드	사망율, 복막투석, 감마글루타밀트랜스퍼라제
초록	Background: Increased gamma-glutamyltransferase (GGT) is associated with oxidative stress and all-cause mortality in the general population. However, its role in peritoneal dialysis (PD) patients is unclear. The aim of this study is determine the association between GGT and mortality in PD patients. Methods: PD patients were selected from Clinical Research Center registry for End Stage Renal Disease cohort in Korea. Patients were categorized into three groups by tertiles of serum GGT levels as follows: Tertile 1, GGT <16 U/L; Tertile 2, GGT=16-27 U/L; Tertile 3, GGT >27 U/L. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with a serum GGT levels of tertile 1 as the reference. Results: A total of 757 PD patients were included. The median follow-up period was 28 months. The multivariate Cox proportional hazard model showed that the higher tertiles of serum GGT levels were associated with higher mortality (Tertile 2: HR 2.00, 95% confidence interval (CI), 1.05-3.84, p=0.036, Tertile 3: HR 1.91, 95% CI, 1.03-3.55, p=0.041) after adjustment for clinical variables. Conclusions: Our data showed that elevated serum GGT level is significantly associated with increased mortality in PD patients.
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