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논문분류	춘계학술대회 초록집
제목	Impact of Peritoneal Dialysate Protein Levels on Mortality in Patients with Peritoneal Dialysis
저자	Ji In Hyun1, Hyung Wook Kim1, Kyung Yoon Chang1, Su-Hyun Kim2,Young Ok Kim1, Dong Chan Jin1, Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim3,Yon-Su Kim4, Shin-Wook Kang5, Nam-Ho Kim6, Chul Woo Yang1, Yong Kyun Kim1
출판정보	2014; 2014(1):
키워드	복막투석액내 단백질, 사망률
초록	Background: Peritoneal protein loss has been reported to be associated with clinical outcomes in peritoneal dialysis (PD) patients. However, the impact of peritoneal dialysate protein levels on clinical outcome is uncertain. In this study, we investigated the association of peritoneal dialysate protein levels and mortality in PD patients Methods: PD patients were selected from the Clinical Research Center registry for End Stage Renal Disease, a multicenter prospective cohort study on dialysis patients in Korea. Patients were categorized into three groups by tertiles of peritoneal dialysate protein levles as follows: Tertile 1, peritoneal dialysate protein concentrations <78.1 mg/dL; Tertile 2, peritoneal dialysate protein concentrations 78.1-100.0 mg/dL; Tertile 3, peritoneal dialysate protein concentrations >100.0 mg/dL. Cox regression analysis was used to calculate the adjusted hazard ratio (HR) of mortality with tertile 1 as the reference. The primary outcome was all-cause mortality. Results: A total of 762 PD patients were included in this study. The median follow-up period was 24 months. Kaplan- Meier analysis showed that all-cause mortality rate were significantly different according to tertiles of peritoneal dialysate protein concentrations (p=0.006, log-rank). Multivariate Cox proportional hazard model showed that highest tertile was associated with increased risk of all-cause mortality compared with the lowest tertile (HR: 1.92, 95% CI: 1.02-3.53) after adjustment for clinical variables. Conclusions: Our data showed that elevated peritoneal dialysate protein levels were significant risk factor for death in PD patients
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