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논문분류	춘계학술대회 초록집
제목	Serum Sodium Level and Outcomes in Patients with End-Stage Renal Disease on Peritoneal Dialysis
저자	Sungjin Chung1, Hyung Wook Kim1, Su-Hyun Kim2, Young Ok Kim1, Dong Chan Jin1,Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim3, Yon-Su Kim4, Shin-Wook Kang5,Nam-Ho Kim6, Chul Woo Yang1, Yong Kyun Kim1
출판정보	2014; 2014(1):
키워드	복막투석, 나트륨, 사망률
초록	Background: Hyponatremia is relatively common in patients with end-stage renal disease (ESRD), and hypernatremia is rare. The prevalence and significance of dysnatremias in Korean patients with ESRD have been poorly studied. The present study aimed to examine associations with serum sodium level measured at baseline with clinical outcomes in patients with ESRD on peritoneal dialysis therapy. Methods: This was a prospective cohort study based on the 1069 patients enrolled in the Clinical Research Center for End-Stage Renal Disease in Korea. The association of serum sodium level with all-cause mortality was examined in Cox models with adjustment for potential confounders. Results: A total of 118 patients died during a median follow-up of 30.7 months. Patients with serum sodium levels of <130 (n=35), 130 to 136 (n=307) and ≥145 mEq/L (n=19) compared with 136 to 145 mEq/L (n=708) had unadjusted mortality hazard ratios of 1.979, 1.962 and 0.000 (p=0.110, p=0.000, and p=0.994), indicating that serum sodium with less than 136 mEq/L has a clinical significance. Patients with <136 mEq/L (n=342) had higher mortality when compared with patients with ≥136 mEq/L (n=727) (hazard ratio 2.021, p=0.000). Furthermore, there were similar associations in models with incremental multivariable adjustments. Conclusions: These results show that hyponatremia is associated with increased mortality in ESRD patients on maintenance peritoneal dialysis, suggesting that identification of dysnatremia would be critical to determining optimal management on electrolyte abnormalities.
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