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제목	The Effects of Icodextrin on Metabolic Indices and Patient Survival in Non Diabetic CAPD Patients
저자	Ji Yoon Park , Seul Ki Kim, Se Yun Kim, Jin Suk Kim, Yu Ho Lee, Yang Gyun Kim,Kyung Hwan Jeong, Ju-Young Moon, Sang Ho Lee, Chun-Gyoo Ihm, Tae Won Lee
출판정보	2014; 2014(1):
키워드	Icodextrin, Metabolic index, Survival, Non Diabetic CAPD
초록	Background: Icodextrin based peritoneal dialysis has shown favorable metabolic effects over conventional glucose based peritoneal dialysis in CAPD patients. However, no studies have been conducted only in non-diabetic CAPD patients on whether icodextrin based peritoneal dialysis improves metabolic control and survival. Method: We reviewed 41 cases of non diabetic CAPD patients who were on CAPD for 5 years retrospectively. Thirty were treated with conventional glucose based peritoneal dialysis(glucose group : mean age 57±16 years) and the other 11 were treated with 3 glucose based solutions during the day and 1 icodextrin dwell during the night (icodextrin group: mean age 61±10 years). We measured variables related to lipid status, HbA1c, and left ventricular ejection fraction and compared all- cause mortality and cardiovascular mortality. Results: There were no significant differences between age, gender, BMI, blood pressure, history of dyslipidemia, total cholesterol, LDL, HDL, triglyceride, HbA1c, and left ventricular ejection fraction of the two groups. Serum LDL (p=0.026) and HbA1c (p=0.021) improved in icodextrin group after 5 years but total cholesterol, HDL, triglyceride, and left ventricular ejection fraction of the groups were not different. Five patients of glucose group developed non- insulin dependent diabetes mellitus during peritoneal dialysis (p=0.3). There were no significant differences in all- cause mortality rate and cardiovascular mortality rate between two groups. Conclusion: These results provide that icodextrin improves metabolic indices in non- diabetic CAPD patients, which is similar to earlier findings. However, mortality rates were not significantly different between two groups and these results may be related to better glycemic control in non diabetic patients. To confirm this data, large randomized prospective studies are needed.
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