대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Comparison of Post-KTP anti-ABO Blood Type Antibody Titers using between Enteric-coated Mycophenolate Sodium and Mycophenolate Mofetil in Patients with ABO Incompatible Renal Transplantation
저자	Jin Ho Lee1, Joon Seok Oh1, Seong Han Yun1, Sung Min Kim1,Yong Hun Sin1, Joong-Kyung Kim1, Jong In Park2
출판정보	2014; 2014(1):
키워드	혈액형 부적합 이식, 면역억제제, 혈액형 항체
초록	Background: ABO-incompatible living kidney transplantation (ABO-iLKT) has been performed to compensate for the shortage of organ donors. Some reports noted that the titers of anti-ABO blood-type IgG antibody before plasma exchange and post-transplant were correlated well with graft survival in ABO-i LKT. After the immunosuppressive regimen introduced using tacrolimus (TAC), mycophenolate mofetil (MMF) and steroid, lower levels of ABO blood type antibody titers have reported in patients with ABO-iLKT. Enteric-coated mycophenolate sodium (EC-MPS) was known to have similar efficacy and safety of compared with mycophenolate mofetil (MMF). So we compared post- transplant anti-ABO blood type antibody titers between using EC-MPS and MMF in patients with ABO-iLKT. Methods: Twenty one subjects performed ABO-iLKT were included in this study. Rituximab, plasma exchange, TAC, MMF, steroid were used before transplantation. 13 subjects’ immunosuppressive regimens were changed MMF to EC-MPS after transplant. Others continued to use MMF. The titers of anti-ABO blood-type IgG and IgM antibody were measured 3, 6, 9, 12 month after transplantation in each group. Antibody titers were presented as 2x and Mann Whitney U test were performed with ∆ x. P values under 0.05 were considered statistically significant. Results: The P values of anti-ABO IgG were 0.31, 0.37, 0.07, 0.17 at 3, 6, 9, 12 month after ABO-iLKT. And The p values of anti-ABO IgM were 0.14, 0.78, 0.67, 0.27 at 3, 6, 9, 12 month after tansplant. There was no statistically significant difference of anti-ABO IgG and IgM titers between using EC-MPS and MMF. Conclusion: The use of MMF and EC-MPS may not have a difference in ABO antibody titers after ABO-ILKT.
원문(PDF)	PDF 원문보기

목록

위로가기