대한신장학회

논문분류	춘계학술대회 초록집
제목	Correlation between Serum NGAL of Post-transplant 2, 3 Weeks and Graft Function Up to 3 Months after Transplantation in Patients with Slow Kidney Graft Function
저자	Jin Ho Lee, Joon Seok Oh, Seong Han Yun, Sung Min Kim, Yong Hun Sin, Joong-Kyung Kim
출판정보	2014; 2014(1):
키워드	신장이식, NGAL, 신기능 지연
초록	Background: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a new, noninvasive diagnostic tool for acute kidney injury. It is known that NGAL associates with delayed graft function; the association has been shown in urine and serum samples taken on the day of, and very soon after, transplantation. And some reported high day 3 NGAL (greater than the mean) was associated with significantly worse kidney function at 3 weeks compared with low NGAL in non-DGF. But little is known about the correlation NGAL with kidney function in patients with slow graft function. The aim of our study was to examine whether serum NGAL levels correlates with the level of kidney function in patients with slow graft function. Methods: Nineteen subjects with slow graft function were included in this study. Serum NGAL levels were measured at 14th and 21th day after transplantation in patients with slow graft function. And serum creatinine and estimated glomerular filtration rate (eGFR; MDRD equation) were measured at 2 and 3 month after transplantation. Correlation analysis was performed with this data. Results: The correlation coefficient between serum NGAL levels (post-transplant 14th day) and serum creatinine of post-transplant 1st, 2nd, 3rd month were 0.476, 0.547, 0.481. And those between NGAL (post-transplant 21th day) and serum creatinine of post-transplant 1st, 2nd, 3rd month were 0.310, 0.364, 0.311. The spearman correlation coefficient between serum NGAL levels (post-transplant 14th day) and eGFR of post-transplant 1st, 2nd, 3rd month were -0.204, -.0412, -0.242. And those between NGAL (post-transplant 21th day) and eGFR of post-transplant 1st, 2nd, 3rd month were -0.076, -0.225, -0.114. The NGAL levels showed a positive correlation with serum creatinine and negative correlation with eGFR but it’s statistically association is not strong. Table1.The Spearman correlation coefficient between serum NGAL levels (14th and 21th day after transplant) with serum creatinine and eGFR (1st, 2nd, 3rd month after transplant) in patients with slow graft function *eGFR: estimated glomerular filtration rate, Cr: Creatinine, POD: post-operative day Conclusion: The serum NGAL levels on 2nd, 3rd week after transplantation may correlate with graft function up to 3 month post-transplant in patients with slow graft function. But the association is not strong, large-scale study will be needed.
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