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논문분류	춘계학술대회 초록집
제목	The Effects of Thyroid Function on Clinical Outcomes after Kidney Transplantation
저자	Jung Nam An1, Jin Ho Hwang2, Hyo Jin Kim3, Sunhwa Lee3, Young Hoon Kim4,Yun Kyu Oh1, Duck-Jong Han4, Su-Kil Park4, Chun Soo Lim1, Jung Pyo Lee1
출판정보	2014; 2014(1):
키워드	신장이식, 갑상선기능
초록	Introduction: The abnormalities in thyroid function, especially triiodothyronine (T3) levels, are observed in patients with chronic kidney disease and end stage renal disease. Few previous studies evaluated the correlation between thyroid function after kidney transplantation and various clinical outcomes, in particular, in Asian patients. Methods: During the period of January 1997 to January 2012, the data about a total of 400 kidney transplantation recipient patients who had thyroid function test (TFT) measured within 5 years after kidney transplantation was analyzed through the retrospective review of electronic medical records of two medical centers. Results: Posttransplant thyroid-stimulating hormone (TSH) level was 1.94±4.23 μIU/mL, free thyroxin (fT4) level was 1.31±0.39 ng/dL, and T3 level was 112.38±34.06 ng/mL. After follow up duration of 84.1±55.4 months and 77.3± 53.0 months, 20 patients (5.0%) were died, and 41 patients (10.3%) were diagnosed allograft failure, respectively. In cox-regression analysis model, posttransplant T3 level was negatively correlated with graft failure (hazard ratio [HR] 0.98; 95% confidence interval [CI] 0.97-0.99; p=0.001), however, posttransplant TSH and fT4 level were not associated. Divided to four groups of T3 level, the risk for development of graft failure was the highest in the lowest group of T3 level (HR 6.90; 95% CI 1.45-32.85; p=0.015). After adjusting other risk factors for graft failure, posttransplant T3 level was significantly associated with kidney allograft failure. In Kaplan-Meier curves, in patients with lower T3 level had the higher risk for allograft failure (Log Rank p-value 0.037). Conclusions: Triiodothyronine (T3) level measured after kidney transplantation is an independent risk factor for allograft failure. Regular measurement and monitoring of TFT can be considered as a crucial marker for prognosis in renal transplant recipient patients.
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