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논문분류	춘계학술대회 초록집
제목	Resveratrol Attenuates Cyclosporine-induced Apoptosis in Renal Proximal Tubule Cells
저자	Su Jung Lee, Seok Hui Kang, Mun Ju Hwang, Eun Woo Choi, Joon Hyuk Seo,Kyu Hyang Cho, Jong Won Park, Kyung Woo Yoon, Jun Young Do
출판정보	2014; 2014(1):
키워드	레스베라트롤, 사이클로스포린, 세포사멸
초록	Cyclosporine nephrotoxicity is an important problem in transplant recipients. We performed this study to evaluate the effect of resveratrol on cyclosporine-induced apoptosis in renal proximal tubule cells. We investigated the effects of resveratrol on human proximal tubular epithelial cells (HK-2). In vitro, HK-2 cells were exposed to media (control), media+cyclosporine (2.0 ug/mL), media+cyclosporine+resveratrol (200 umol/L), and media+resveratrol. Preliminary experiments evaluating a dosage of resveratrol on apoptosis showed a maximum response at concentration of 200 umol/L). Protein expression of apoptosis markers were evaluated by western blot assay. Cyclosporine decreased the phosphorylation of cAMP response element-binding protein (CREB). Cotreatment with resveratrol increased the phosphorylation of CREB. Cyclosporine resulted in an increase of the expression of apoptotic marker such as Bax and associated with a decrease in the expression of anti-apoptotic marker such as Bcl-2. Co treatment with resveratrol showed a restoration of these changes. Our results suggest that resveratrol has a protective effect on cyclosporine induced apoptosis in renal proximal tubule cells.
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