| 저자 |
Kyung Don Yoo1, Jeonghwan Lee2, Hyunjeong Cho1, Hyunwook Kim3, Dong-Ryeol Ryu4,Yoon Kyu Oh5, Chun Soo Lim5, Dong Ki Kim1, Yon Su Kim1, Jung Pyo Lee5 |
| 초록 |
Background: Korean Society of Nephrology(KSN) has collected data about endstage renal disease (ESRD) patients in Korea, and reported survival data annually. However, only about 70% of ESRD patients have been registered. Therefore, we accessed to the Korean Health Insurance Review and Assessment Service (HIRA) database and tried to clarify clinical outcomes of kidney transplantation in newly diagnosed ESRD patients.
Method: Among all the incident dialysis patients between 2005 and 2008 in Korea, the patients who were undergone kidney transplantation between 2005 and 2009 were included. In this study, patient survival rate, post-transplant cardiovascular event, and composite outcome were compared according to pre-transplant dialysis modality, dialysis duration, diabetes mellitus and modified Charlson comorbidity index (mCCI) score.
Results: A total of 35541 patients were extracted from HIRA database and 1563 kidney transplant patient were included analysis. The mean age was 40.7±10.9years and male patients were 614 (39.3%). About one-fourth of patients had diabetes (24.4%). We compared clinical outcomes between two groups divided by the intention-to-treat dialysis modalities. There are no difference of survival rate according to dialysis modalities between 1148 hemodialysis patients (73.4%) and 415 peritoneal dialysis patients (26.5%) (p=0.854). In the hemodialysis patient, pre-transplantation dialysis duration was an independent risk factor for all-cause mortality after adjustment for age, sex, diabetes, health insurance service type and mCCI score (hazard ratio 3.409, 95% confidence interval 1.561-7.445, p=0.002). In peritoneal dialysis patients, there were no significant risk factors for clinical outcomes.
Conclusion: Incident hemodialysis patients had different outcomes after kidney transplantation according to the dialysis duration. Long-term hemodialysis might be associated with higher cardiovascular mortality. |