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논문분류	춘계학술대회 초록집
제목	Predictive Value of Urinary and Serum Biomarkers in Young Children with Febrile Urinary Tract Infections
저자	Hyung Eun Yim1, Hyungshin Yim2, Eun Soo Bae1, Sang Uk Woo2, Kee Hwan Yoo1
출판정보	2014; 2014(1):
키워드	세균 감염, 생체표지자, 소아
초록	Background: Early predictive biomarkers for the diagnosis and management of febrile urinary tract infections (UTIs) can be valuable in children. Methods: Seventy-three patients with febrile UTIs (46 acute pyelonephritis [APN] and 27 lower UTIs), and 56 healthy children were enrolled. Urine levels of neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) and serum levels of cystatin C (sCysC) were measured. Results: uNGAL/creatinine (Cr) and uKIM-1/Cr were higher in the UTI group than those in the controls (p<0.05). uNGAL/Cr and sCysC also increased in patients with APN compared to those with lower UTIs (p<0.05). uNGAL/Cr levels in both the APN and UTI groups decreased after antibiotic treatment, compared to those before treatment (p< 0.05). uNGAL/Cr was correlated with serum levels of white blood cells, C-reactive protein, CysC, and uKIM-1/Cr (p< 0.05). uKIM-1/Cr was also correlated with sCysC (p<0.05). Receiver operating curve analyses showed a good diagnostic profile of uNGAL/Cr and uKIM-1/Cr for identifying UTI (areas under the curves [AUCs], 0.9 and 0.66, respectively) and of uNGAL/Cr and sCysC for predicting APN (AUCs, 0.78 and 0.72, respectively). Conclusions: uNGAL, uKIM-1, and sCysC may be useful for predicting and managing febrile UTIs in children.
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