대한신장학회

논문분류	춘계학술대회 초록집
제목	Correlation between Vitamin D and Albuminuria in Chronic Kidney Disease Patients: The KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
저자	Yung Ly Kim1, Mi Jung Lee1, Tae-Hyun Yoo2, Kook-Hwan Oh2, Dong Wan Chae3,Young-Hwan Hwang4, Kyu Beck Lee5, Soo Wan Kim6, Wookyung Chung7,Yong Soo Kim8, Yeong-Hoon Kim8, Sue Kyung Park9, Curie Ahn1, Kyu Hun Choi1
출판정보	2014; 2014(1):
키워드	비타민 D, 알부민요증, 만성신부전
초록	Background: Vitamin D plays an important role in human health. However, vitamin D deficiency is commonly observed in the general population and among patients with chronic kidney disease. Low vitamin D levels have been associated with the pathogenesis of kidney disease. Although albuminuria is a marker of kidney disease, few studies have examined vitamin D levels and albuminuria simultaneously. Hence, this study investigated the association between vitamin D status and degrees of albuminuria. Methods: This retrospective study included 927 chronic kidney diseasepatients from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD). The current study evaluated the serum levels of creatinine, calcidiolor (25-hydroxyvitamin D), calcitriolor (1,25-dihydroxyvitamin D), estimated glomerular filtration rates, and spot urine albumin- to-creatinine ratios. Results: Among the 927 patients, 470 (50.7%) were women and 457 (49.3%) were men. The mean serum levels of creatinine, calcidiol, and calcitriol, were 1.95±1.2 mg/dL, 18.29±9.9 ng/mL, and 31.98±17.2 ng/mL, respectively. The mean estimated glomerular filtration rate, determined using the Modification of Diet in Renal Disease (MDRD) equation, was 48.2 mL/min/1.73m2. Patients were divided into two groups: normal-to-mild albuminuria (<30 mg/g) and moderate-to-severe albuminuria (≥30 mg/g). Accordingly, there were 498 (53.7%) in the former group, and 429 (46.3%) in the latter group. Negative correlations were observed between albuminuria and serum calcitriol (p<0.001), and moderate-to-severe albuminuria and calcidiol (p=0.002), which were statistically significant. Conclusions: A significant correlation exists between vitamin D levels and albuminuria. However, it remains to be confirmed if vitamin D deficiency is a causal and reversible factor in the development of albuminuria.
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