대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Synergic Renoprotective Effects of Green Tea Extract and Candesartan on Streptozotocin-induced Diabetic Nephropathy in Mice
저자	Byung Chul Shin, Hyung Nam Kim, Dong Hyun Kim, Hyun Lee Kim, Jong Hoon Chung
출판정보	2014; 2014(1):
키워드	녹차추출물, 당뇨병성 신증, 칸데사탄
초록	Background: Diabetic nephropathy (DMN) is one of the most serious complications in diabetes mellitus and has been the most common cause of end-stage renal diseases. Green tea extracts (GTE) have antioxidant properties and are known to be the most abundant in green tea. Inflammatory cytokines, mainly IL-1 and IL-6, as well as TNF-α, are involved in the development and progression of DMN. We examined whether GTE with candesartan (CDS) could be synergic protective effects on DMN and relationship of cytokines in mice. Methods: The mice (n=50) were divided into 5 groups (n=10 each group). Control group was given intraperitoneal injection of 0.9% saline. Streptozotocin (STZ) group was given intraperitoneal injection of STZ 200 mg/kg and induced diabetic nephropathy. CDS group was received 30 mg/kg CDS by oral route and GTE group was received GTE 100 mg/kg by oral route. GTE+CDS group was received GTE 100 mg/kg with CDS 30 mg/kg from 4 weeks to 16 weeks. Serum glucose, blood urea nitrogen, serum creatinine, urine volume and urine protein amounts were measured. Mouse cytokine array panel A kit was used to examine the relative levels of mouse cytokines and chemokines, and histopathologic staining of mice’s kidney were performed. Results: Compared with control group, STZ-group showed an increase in blood glucose, blood urea nitrogen, creatinine levels and urine protein amounts, and a decrease in body weight. All the above parameters were significantly reversed with GTE treatment, especially GTE+CDS group. IL-1 α/β, IL-16, TNF-α, and C5/C5a levels are significantly elevated in STZ group compared with control group and reversed in GTE and GTE plus CDS groups. GTE+CDS treated mice kidney showed a reduced expression of above parameters and a reserved pathologic findings. Conclusions: These results suggest that GTE with CDS has synergic renoprotective effects on STZ-induced DMN mice by suppression of inflammatory cytokines. The potential use of GTE with CDS is suggested in the treatment of diabetic nephropathy.
원문(PDF)	PDF 원문보기

목록

위로가기