대한신장학회

논문분류	춘계학술대회 초록집
제목	Low Serum Magnesium is associated with Coronary Artery Calcification in Relatively Healthy Koreans
저자	Shin Yeong Lee, Young Youl Hyun, Kyu Beck Lee, Hyang Kim
출판정보	2014; 2014(1):
키워드	저마그네슘혈증, 관상동맥 석회화, 아가츠톤 점수
초록	Objective: Magnesium is one of major intracellular divalent cation in our body. Magnesium is not only necessary for the regulation of neuromuscular function, but also known to have anti-inflammatory and anti-platelet function. Recent studies have suggested its association with metabolic or cardiovascular diseases and hypomagnesemia was reported as a risk factor for diabetes or coronary artery disease, although the mechanism is not well known. One recent study has shown that hypomagnesemia is associated with carotid artery alteration, but there is no previous study on its relation to coronary artery calcification (CAC), another important marker of cardiovascular risk. In this study, we investigated the relationship between hypomagnesemia and CAC by using health check-up data. Methods: We analyzed 34,965 participants who underwent a coronary MDCT as a health check-up program at a tertiary hospital in Korea. The check-up program also measured serum magnesium level and was done in 2010-2012. Coronary artery calcification was analyzed by using CACs (CAC score) developed by Agatston et al and CAC was defined as CACs>100 in this study. Logistic regression analysis was used to estimate the odds ratio for CAC. Results: Participants were divided into three groups according to their serum magnesium level: hypomagnesemia, <1.9 mg/dL (n=941); normal, 1.9-2.3 mg/dL (n=32,732); hypermagnesemia, >2.3 mg/dL (n=1,292). CACs were different between hypomagnesemia, normal and hypermagnesemia groups (15±91 vs 8±71 vs 10±57, p=0.0043). The percentages of participants with CAC were 3.9, 1.6 and 2.5 in each group. In multivariate analysis, hypomagnesemia was associated with CAC after adjustment for age, sex, body mass index, diabetes, hypertension, cardiovascular disease, systolic blood pressure, diastolic blood pressure, LDL cholesterol, HDL cholesterol, eGFR, hsCRP, current smoking status, alcohol intake and vigorous exercise frequency. The odds ratio of hypomagnesemia group for CAC compared with normal group was 2.00 (1.34-2.97, p=0.001). Conclusion: Low serum magnesium level was associated with coronary artery calcification in relatively healthy Koreans. Further studies are warranted to verify the causal relationship and the role of magnesium in the development of cardiovascular disease.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정