대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Serum Uric Acid is an Independent Risk Factor for Coronary Artery Calcification in Asymptomatic Obese Individuals
저자	Mi Ok Cho, Hyeong Cheon Park, Sung Kyu Ha, Hoon Young Choi, Ah Ran Choi, Tae Hoon Kim
출판정보	2014; 2014(1):
키워드	요산, 관상동맥 석회화지수, 비만
초록	Introduction: Hyperuricemia is frequently observed in obesity, which is well known coronary heart disease risk factor. Recent evidences suggest that high serum uric acid (sUA) concentration may act as a risk factor for cardiovascular complications, especially in high risk patients. Coronary artery calcium score (CACS), assessed by coronary CT angiography, is a good marker of atherosclerosis that represents the degree of atheromatous plaque burden and a predictor of cardiovascular events. This study investigated the relationship of sUA with CACS using non-invasive coronary CT angiography in asymptomatic obese subjects. Methods: We consecutively enrolled 5,491 asymptomatic subjects without history of coronary disease who underwent coronary CT angiography as part of a general health examination. Data were analyzed using multivariate logistic regression models to identify the relationship between CACS and clinical variables including sUA. Results: Among the study subjects, male 62.3%, mean (±SD) age 52.99±9.544, body mass index (BMI) 23.99±3.131 kg/m2, CACS 36.16±147.987, sUA 5.439±1.3698. Participants were subdivided in two groups, based on their BMI. 2,255 subjects were obese (BMI≥25 kg/m2), mean BMI 21.95 kg/m2 and 3,236 participants were non-obese (BMI <25 kg/m2), mean BMI 26.90 kg/m2. In both groups, three variables such as gender, age and hypertension had a positive correlation with CACS>100. After adjusting for these confounding factors, diabetes, CPP and sUA were risk factors for high CACS (>100) in obese subjects (OR:1.753, 95%C.I: 1.117-2.750, p-value<0.05; OR: 1.592, 95%C.I: 1.214-2.086, p-value<0.05; OR:1.145, 95%C.I: 1.013-1.294, p-value<0.05, respectively). However, in non-obese subjects, diabetes, CPP and uric acid were not independently associated with CACS (CACS>100). Conclusion: In obese subjects, diabetes, elevated serum levels of CPP and uric acid are significantly associated with increased CACS independent of other traditional risk factors.
원문(PDF)	PDF 원문보기

목록

위로가기