대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	추계학술대회 초록집
제목	Circulating Sclerostin as a Marker of Bone Health and Disease
저자	Hyeon Seok Hwang
출판정보	2014; 2014(2):
키워드
초록	In recent years study, rare human bone disorders led to the identification of sclerostin that regulates the important signaling pathways in bone formation. Sclerostin is a soluble inhibitor of wnt signaling that bind to the LRP5/6 coreceptors and impede formation of an active wnt receptor complex. Sclerostin antagonizes the bone formation by repressing differentiation and proliferation of osteoblasts. It also promotes osteoblast apoptosis. In experimental animal model, blocking sclerostin action by a specific antibody induces more rapid repair of bone loss and an osteoanabolic effect. In human bone, sclerostin expression is restricted to osteocytes, but osteoclasts, osteoblasts, and bone lining cells do not express sclerostin. It is suggested that sclerostin plays a significant role in the pathogenesis of renal osteodystrophy. Large number of studies report that circulating sclerostin level measured in predialysis CKD and dialysis patients is correlated with their demographic or biochemical parameters. More recently, sclerostin was also shown to be expressed in calcifying vasculature in CKD patients. Therefore, we review here the current knowledge of the regulation of sclerostin, mechanism of action, and its potential as a circulating marker of bone health and disease in CKD patients.
원문(PDF)	PDF 원문보기

목록

위로가기