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논문분류	춘계학술대회 초록집
제목	Suggested Role of Adiponectin in Reciprocal Relationships between Pulse Wave Velocity and Bone Mineral Density in CKD Patients
저자	Seon Ha Baek, Shin Young Ahn, Sung Woo Lee, Mi-Yeon Yu, Sejoong Kim, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Curie Ahn
출판정보	2015; 2015(1):
키워드	Adiponectin, 맥파 전달 속도, 골밀도
초록	Background: Although adiponectin plays a beneficial role in the regulation of insulin action and atherosclerosis, the role of adiponectin remains a controversy in patients with chronic kidney disease (CKD). Methods: A total of 1,310 patients (male/female=794/516) with CKD stage 1 to 5 who enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) from April 2011 to December 2013. We measured serum total adiponectin and examined the association between adiponectin, bone mineral density (BMD) measured by dual energy X-ray absorptiometry, and pulse wave velocity (PWV)calculated by mean value of both brachial-ankle (ba) PWV. Results: Increasing quintiles of serum adiponectin levels were associated with lower body mass indices, estimated glomerular filtration rate, triglycerides, BMD, albumin and higher urinary protein creatinine ratios, PWV, phosphorous, intact PTH. Femur neck T-score inversely correlated with ba PWV (r=-0.092, p=0.005)in male CKD, however, this association was no significant for female CKD(r=-0.031,􀀁p=0.456). Adiponectin was inversely associated with femur neck T-score for both male and female CKD patients (male: r=-0.127, p=0.001; female: r=-0.138, p=0.002). Adiponectin was positively associated with ba PWV for male CKD (r=0.091, p=0.008), but not for female CKD (r=-0.024, p=0.545). Conclusion: Adiponectin, BMD, and PWV were associated with each other in male CKD patients. The findings suggested that adiponectin have the role in reciprocal relationships between PWV and BMD in not female but male CKD patients.
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