대한신장학회

논문분류	춘계학술대회 초록집
제목	Resveratrol Activates Adiponectin Receptor-1 and -2 in Type 2 Diabetic Nephropathy
저자	Hoon Suk Park, Ji Hee Lim, Min Young Kim, Yaeni Kim, You Ah Hong, Sun Rung Choi, Sungjin Chung, Seok Joon Shin, Hyung Wook Kim, Bum Soon Choi, Yong Soo Kim, Yoon Sik Chang, Cheol Whee Park
출판정보	2015; 2015(1):
키워드	당뇨병성 신증, 레즈베라트롤, 아디포넥틴
초록	Aim/hypothesis: Adiponectin from adipose tissue has multiple function including insulin sensitization, anti-inflammation and anti-atherogenesis in various organs through the activation of AMPK and PPARα via adiponectin receptor (AdipoR)-1 and AdipoR-2, respectively. It has been also suggested that adiponectin confers renoprotective effects in type 1 diabetes. Many of the effects of resveratrol are consistent with the activation of AMPK-PGC-1, which play key roles in the regulation of lipids and glucose homeostasis, and in the control of oxidative stress. Methods: Male db/db mice and db/m mice at 8 weeks of age treated with or without resveratrol (20 mg/Kg) for 12 weeks. We measured renal functional and histological changes. Intrarenal Adipo R-1 and R-2, AMPK, SIRT1and FoxO1 and 3a expressions and subsequent oxidative stress markers were also measured. Results: In db/db mice, resveratrol decreased albuminuria, glomerular matrix expansions, inflammation and increased apoptosis in the glomerulus. Resveratrol increased the phosphorylation of AMPK and SIRT1, and decreased phosphorylation of the key downstream effecters, the FoxO1 and FoxO3a, through increases in AdoipoR-1 and AdipoR-2 in the renal cortex. Furthermore, resveratrol increased the expressions of PGC-1-ERR-1a, decreased sterol-regulatory element-binding protein1 (SREBP1)and increased phosphorylated acetyl-CoA carboxylase (ACC), which lowered the non-esterified fatty acid and triacylglycerol contents in the kidneys, resulting in decreases in apoptosis and oxidative stress associated with eNOS activation. In cultured HGECs, resveratrol prevented HGECs from high glucose-induced oxidative stress and apoptosis via increases in the expression of AdipoR-1 and AdipoR-2 and their downstream effecters, the phosphorylation of AMPK and SIRT1 signaling. Conclusions/interpretations: The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the increases in expressions of AdipoR-1 and Adipo-R2 and subsequently phosphorylates AMPK, which seems to be related to prevent lipotoxicity-induced renal damage in the kidneys.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정