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논문분류	춘계학술대회 초록집
제목	Risk Factors associated with the Progression of Osteoporosis in Kidney Transplant Recipients
저자	Woo Yeong Park1, Byung Ha Chung2, Seung Yeup Han1, Bum Soon Choi2, Cheol Whee Park2, Yong-Soo Kim2, Chul Woo Yang2
출판정보	2015; 2015(1):
키워드	신장이식, 골다공증, 골밀도
초록	Background: Kidney transplant recipients (KTR) showed high prevalence of osteoporosis because of multifactorial conditions. The aim of this study is to investigate the risk factors associated with the progression of osteoporosis in KTRs. Methods: A total of 207 KTRs were enrolled from January 2011 to December 2013. We checked bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA) method before KT and at a year after KT, and classified the severity of osteoporosis by the classification of the World Health Organization. We also measured serum 25(OH)-D level, intact parathyroid hormone (iPTH), calcium, phosphorus when BMD was measured. Risk factors related with the progression of osteoporosis were analyzed by multivariate logistic regression analyses. Results: After transplantation, 143 (69.1%) KTRs showed deterioration of BMD score; 14 patients (6.8%) did not show significant change and only 50 (24.1%) patients showed improvement of BMD score, hence finally the prevalence of osteoporosis increased from 41.5% to 47.3% after KT compared to before KT. In addition, the mean T-score of femur neck area was -2.3±1.1 after KT and got worse than -2.1±1.2 before KT. The multivariate logistic regression analyses showed the risk factors in the pre-transplant status affecting the post-transplant bone loss were biopsy-proven acute rejection, BMD score before KT and variation of intact PTH. Conclusions: In many KTRs, osteoporosis showed progression during post-transplant 1 year, and biopsy-proven acute rejection, BMD score before KT and increase of intact PTH were independent risk factors associated with the progression of osteoporosis.
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