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논문분류	춘계학술대회 초록집
제목	Clinical Implication of Serum Free Light Chain in Patients with IgA Nephropathy
저자	Woo Jin Jung1, Na Kyoung Hwang1, Sang Heon Song1, Jin Suk Kang1, Il Young Kim1, Dong Won Lee1, Soo Bong Lee1, Harin Rhee1, Eun Young Seong1, Ihm Soo Kwak1, Min Ja Baek2, Su Jin Kim2, Na Young Jeong2
출판정보	2015; 2015(1):
키워드	IgA 신장병증,경쇄 면역글로불린,단백뇨
초록	Backgrounds: Although free light chains (FLCs) which are produced in excess during immunoglobulin synthesis by plasma cells have been identified as a predictive factor of mortality in chronic kidney disease as well as a tool for diagnosis of plasma cell dyscrasia, little is known about the clinical implication of FLCs in patients with IgA nephropathy. Objectives: To investigate the relationship between the serum level of kappa and lambda FLCs and clinical markers in patients with IgA nephropathy. Methods: This retrospective study analyzed consecutive 42 patients with biopsy-proven IgA nephropathy without renal function impairment (estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73m2) at the Pusan National University Hospital from January 2010 to December 2013. Clinical and laboratory data were collected by medical records reviewing. Results: The median (inter-quartile range) of kappa lambda were 18.8 (14.4-24.5) and 21.5 (17.3-25.5), respectively. In correlation analyses, log-transformed kappa and lambda FLCs were both positively associated with age, mean arterial pressure, IgG and log-transformed urinary protein creatinine ratio (uPCR), and negatively associated with albumin and hemoglobin levels. In multivariate regression models, increased kappa and lambda FLCs were both independently associated with higher log-transformed uPCR after adjusting confounding factors. However, no significant association of FLCs with eGFR and pathologic classification was observed. Conclusion: The cFLC level was independently associated with the magnitude of proteinuria in patients with IgA nephropathy. Our finding suggests that cFLC can be a prognostic maker in IgA nephropathy.
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