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논문분류	춘계학술대회 초록집
제목	Transgenic Mice with High Endogenous Omega-3 Fatty Acids are Protected from Ischemia-Reperfusion-Induced Acute Kidney Injury
저자	Won Min Hwang1, Se Hee Yoon1, En Jung Cha2, Seung-Yun Han3, Jaeku Kang4, Moon Hyang Park2, Sungro Yun1
출판정보	2015; 2015(1):
키워드	급성신부전,허혈성재관류손상,오메가3지방산
초록	Background: Acute kidney injury (AKI) is common clinical event and has high mortality rate despite advanced curative strategies. Several studies found that omega-3 polyunsaturated fatty acid(PUFA) diet reduces kidney dysfunction followed by ischemic injury. However oral appliance of omega-3 PUFA, in fact, can cause much variability arisen from diet procedure. fat-1 transgenic mouse produce abundant omega-3 PUFA, result in balanced omega-6 : omega-3 ratio than wild type mouse. The purpose of this study, therefore, is to see whether omega-3 PUFA has advantages in AKI caused by ischemic injury using fat-1 transgenic mice. Methods/Materials: Bilateral kidneys were subjected to 30 minutes of ischemia, renal ischemia-reperfusion injury (IRI) was performed. Animals(fat-1 mice and C57BL/6 mice) are sacrificed 24hours and 72 hours of reperfusion. The effects of omega-3 PUFA on renal IRI were evaluated in terms of renal function, tubular necrosis, inflammatory cell infiltration. After that renal function and severity of renal injury were estimated. Result: fat-1 mice could reduce to increased BUN, serum creatinine and tissue Kim-1 levels and reduce neutrophil infiltration in body after IRI, compared with Wild Type mice. Conclusions: Long-term and high dose of omega-3 supplement can protect renal function and facilitate renal recovery following IRI.
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