대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Early Activation of Inflammasome in Acute Kidney Injury after Renal Sympathetic Denervation in Pig
저자	Dong Won Lee1, Jeong Su Kim2, Il Young Kim1, Harin Rhee1, Min Jung Kim1, Joo Hui Kim1, Eun Young Seong1, Sang Heon Song1, Soo Bong Lee1, Ihm Soo Kwak1
출판정보	2015; 2015(1):
키워드	Inflammasome,신장 교감신경절제술,급성신질환
초록	Objectives: Renal sympathetic denervation (RDN) is available and implemented as a strategy for the treatment of resistant hypertension.In the aspect of chronic safety, renal function, as assessed by serum creatinine, eGFR(MDRD), and cystatin C was reported to be unchanged from baseline at 6 months. We investigated whether RDN might cause subtle inflammation and subclinical damage in the early phase of acute kidney injury (AKI). Methods: Female pigs were divided into 6 groups; normal control (group A), Sham-operated control (group B), contrast media control (group C), and renal sympathetic denervation groups subdivided into 3 groups according to the time of sacrifice; immediately (group D), 1 week later (group E), and 2 weeks later (group F) after RDN. We checked IL-1α, 1β, 18, 6, 10, TNF-α, cystatin C, caspase-1, ASC, and NLRP3 as early biomarkers of inflammation and AKI. Results: There were no significant changes in group B and C compared to group A. BUN, serum creatinine, cystatin C, urine protein/creatinine ratio, and urine albumin/creatinine ratio showed a tendency to increase in group D and E and then decrease in group F with no statistical significance. Pro-inflammatory cytokines, IL-1β, 18 increased in group D and E (p<0.05 vs. A), and decreased in group F (p<0.05 vs. D, E) significantly. Casapse-1 activity, ASC, and NLRP3 expressions were also increased in group D (p<0.05 vs. group A), and decreased in group E and F (p<0.05 vs. group D). Conclusion: RDN did not cause clinically significant damages on kidneys. However RDN can induce the activation of pro-inflammatory cytokines, caspase-1 and NLRP3 inflammasome, and then transiently self-limited acute kidney injury.
원문(PDF)	PDF 원문보기

목록

위로가기