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논문분류	춘계학술대회 초록집
제목	Effects of DPPIV Inhibitor on Renal Function in Mice Model of Adriamycin Induced Nephropathy
저자	Hye Sook Min1, Sung Jin Kim2, Ki Tae Kim1, Jin Joo Cha1, Jung Eun Kim1, Jung Yeon Ghee1, Ji Eun Lee3, Hyun Wook Kim3, Jee Young Han4, Young Sun Kang1, Dae Ryong Cha1
출판정보	2015; 2015(1):
키워드	DPPIV,Adriamycin 유도 신병증,족세포
초록	Background: The murine model of adriamycin(ADR) induced nephropathy is characterized by severe proteinuria, development of podocyte injury and glomerulosclerosis. The aim of the present study is to investigate the mechanism and preventive effect of fibrosis in glomerular, tubular and interstitial tissue associated with DA1229 treatment in ADR-induced nephropathy. Methods: The 6-week-old balb/c mice were divided in four groups as follows: Group 1) untreated with DA1229 after injection of ADR(control of Group 2), Group 2) immediately treated with DA1229 for 3 weeks after injection of ADR (prevention protocol), Group 3) untreated with DA1229 after injection of ADR(control of Group 4), Group 4) treated with DA1229 for 2 weeks after 3 weeks of injection of ADR(therapeutic protocol). Results: Treatment with DA1229 showed the preventive effect on weight gain and renal hypertrophy after 5 weeks of injection of ADR. Plasma DPPIV activity was significantly decreased in treatment with DA1229. DPPIV activity in kidney was significantly increased after injection of ADR and decreased in treatment with DA1229. Proteinuria and albuminuria was significantly increased in injection of ADR. Interestingly, proteinuria was significantly decreased in both prevention and therapeutic treatment groups. Inflammatory and fibrotic molecules in kidney tissue were significantly inhibited in treated with DA1229. Urinary excretion of nephrin was significantly decreased in treated with DA1229. Infiltration of macrophages and glomerular and tubular fibrosis were increased after injection of ADR and significantly decreased in treated with DA1229. Conclusion: Our data suggest that renoprotective effects of DA1229 in ADR-induced nephropathy may be associated with protective effect of podocyte injury and anti-inflammatory effect. DA1229 may be used as potential therapeutic agents in a variety of glomerular diseases inducing proteinuria.
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