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논문분류	춘계학술대회 초록집
제목	Effects of Highly Selective Adenosine 3 Receptor Antagonist on Renal Function in Mice Model of Adriamycin Induced Nephropathy
저자	Hye Sook Min1, Sung Jin Kim2, Ki Tae Kim1, Jin Joo Cha1, Jung Eun Kim1, Jung Yeon Ghee1, Ji Eun Lee3, Hyun Wook Kim3, Jee Young Han4, Young Sun Kang1, Dae Ryong Cha1, Hun Joo Ha5, Lak Shin Jeong6
출판정보	2015; 2015(1):
키워드	A3AR 억제제,Adriamycin 유도 신병증,족세포
초록	Background: Concentration of adenosine in normal kidney increases markedly during renal hypoxia and ischemia. Previous studies have reported that mice lacking renal A3 adenosine receptor (A3AR) show significant protection against acute kidney injury, such as ischemia-reperfusion injury and myoglobinuira-induced injury. A recent study reported that A3AR antagonist blocked the development and attenuated the progression of renal fibrosis. Adriamycin (ADR)-induced nephropathy model has developed podocyte injury, which resulted in severe proteinuria and progressive glomeurulosclerosis. The aim of the this study is to investigate the mechanism and preventive effect of fibrosis in glomerular, tubular and interstitial tissue associated with highly selective adenosine 3 receptor antagonist (LJ1888) treatment in ADR-induced nephropathy Methods: We designed three animal groups as following: 1) 6-week-old balb/c mice(control), 2) untreated with LJ1888 after injection of ADR (11 mg/kg), 3) treated with LJ1888 (10 mg/kg) for 2 weeks after 5 weeks of injection of ADR. Results: Body weight was significantly decreased in both injection of ADR and treated with LJ1888 at 7 weeks. Proteinuria and micro-albuminuria were significantly increased after injection of ADR and significantly decreased in treated with LJ1888. Urinary excretion of nephrin was significantly increased at 7 weeks after injection of ADR and significantly decreased in treated with DA1229. Urine isoprostane and lipid peroxide, which reflect oxidative stress markers in kidney, were significantly increased after injection of ADR and significantly decreased in treated with LJ1888. Conclusion: Our results suggest that renoprotective effects of LJ1888 in ADR-induced nephropathy may be associated with protective effect of podocyte injury. LJ1888 may be used as potential therapeutic agents in a variety of glomerular diseases inducing proteinuria.
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