대한신장학회

논문분류	춘계학술대회 초록집
제목	Health Related Quality of Life in KNOW-CKD: Association between Malnutrition, Inflammation, Atherosclerosis, Lifestyle and HRQOL
저자	Jea Eun Lee1, Kyu-Beck Lee1, Young Youl Hyun1, Hyang Kim1, Kook-Hwan Oh2 Curie Ahn2, Sue Kyung Park3, Joongyub Lee3, Dong Wan Chae2, Kyu Hun Choi4 Yong-Soo Kim5, Wookyung Chung6, Young-Hwan Hwang7, Soo Wan Kim8, Yeong Hoon Kim9
출판정보	2015; 2015(1):
키워드	만성콩팥질환,건강관련 삶의 질
초록	Background: Health-related quality of life (HRQOL) can be defined as one’s physical, social, or emotional well-being is affected by a medical condition, socioeconomic status and other factors. HRQOL is diminished in patients with end-stage renal disease patients compared with health individuals, and low HRQOL is associated with a greater inflammatory status, poor nutrition, increased hospitalization and high mortality. However, much less is known about the association of HRQOL on patients with predialysis chronic kidney disease (CKD). Methods: 1,529 CKD patients were enrolled in the prospective KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) study between 2011-2013. We analyzed 1,416 participants from this cohort who underwent baseline examination and HRQOL measure. HRQOL was measured using the Short Form-36 (SF-36, Korean edition), which included physical component score (PCS) and mental component score (MCS). We used multivariate linear regression to analyze the association between malnutrition, inflammation, atherosclerosis, lifestyle and HRQOL. Results: Estimate glomerular filtration rate (eGFR) and albumin creatinine ration (ACR) was not associated with HRQOL after adjustment for comorbid condition, socio-economic states, hemoglobin, PTH, hsCRP, albumin, 24 urine creatinine, dietary protein intake, coronary calcium score (CCS), pulse wave velocity (PWV), left ventricular hypertrophy (LVH). Dietary protein intake (betha 0.12, 95%CI 0.04 to 0.18) and hsCRP (betha-0.08, 95%CI -1.82 to -0.16) were associated with PCS, but CCS, PWV and LVH were not associated with PCS. Dietary protein intake (betha 0.11, 95 %CI 0.03 to 0.18) was associated with MCS, but hsCRP, CCS, PWV and LVH were not associated with MCS. Smoking, high salt diet and obesity were paradoxically associated with high HRQOL. Conclusions: Renal function (eGFR and ACR), atherosclerosis and inflammation are not associated with HRQOL in patients with CKD. Nutrition status is associated with PCS and MCS. Inflammation is associated with PCS, but not MCS. Lifestyle factors show paradox in HRQOL that smoking, high salt diet and obesity are associated with high HRQOL.
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