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논문분류	춘계학술대회 초록집
제목	Paricalcitol, Vitamin D Receptor Activator Prevents Cardiovascular Fibrosis and Inflammation of 5/6 Nephrectomy Rat on Preitoneal Dialysis
저자	Dong Won Lee, Harin Rhee, Min Jung Kim, Joo Hui Kim, Il Young Kim, Eun Young Seong, Sang Heon Song, Soo Bong Lee, Ihm Soo Kwak
출판정보	2015; 2015(1):
키워드	복막투석,비타민 D,심혈관 섬유화
초록	Objectives: Vitamin D receptor expressions in kidney, myocardium and also peritoneum suggest the potential role of vitamin D receptor activators (VDRAs). We investigated whether the selective VDRA, paricalcitol (19-nor-1.25-dihydroxyvitamin D2) suppresses rennin-angiotensin-aldosteron system (RAAS), and thus reduces cardiovascular inflammation and fibrosis as well as peritoneal pathology of 5/6 nephrectomy rat model on peritoneal dialysis (PD). Methods: Male Wistar rats were divided into 4 groups; Sham operated normal control (group A), 5/6 nephrectomized ESRD control (group B), 5/6 nephrectomy with PD (group C), same as group C and paricalcitol (200 ng IP, three times/week) (group D). PD was performed for 4 weeks via silicone peritoneal catheter implanted into rat peritoneal cavity and tunneled subcutaneously. Results: After 4 weeks of PD, BUN and serum creatinine in group C and D were decreased (p<0.05 vs. group B). D/P urea in group C and D were significantly increased (p<0.05). Paricalcitol treatment (group D) increased E-cadherin, and decreased αSMA and TGF-β significantly (p<0.05, vs. group C). Peritoneal fibrosis scores and neovascularization in group D were decreased (p=NS vs. group C). Peritoneal inflammation scores, thickness(μm) and αSMA staining in group D were decreased (p<0.05 vs. group C). Moreover, myocardial fibrosis scores and aortic inflammation scores were decreased in group D (p<0.05 vs. group C). Conclusions: A selective VDRA, paricalcitol attenuates cardiovascular as well as peritoneal inflammation and fibrosis of 5/6 nephrectomy rat model on PD.
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