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논문분류	춘계학술대회 초록집
제목	Vitamin D Deficiency Is Associated with Increased Bacterial Infections After Kidney Transplantation
저자	Young-Jae Park, Eugene Kwon, Hee-Yeon Jung, Su-Hee Kim, Min-Young Seo, Sukyung Lee, Jong-Hak Lee, Sun-Young Cho, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
출판정보	2015; 2015(1):
키워드	비타민D,신장이식,감염
초록	Background: Vitamin D status was known to be associated with allograft and patient survival in kidney transplant recipients (KTRs). However, there are few studies about the association between vitamin D levels and post-transplant infections. This study investigated the impact of vitamin D deficiency on the development of infections after kidney transplantation. Methods: We enrolled KTRs who measured 25-(OH) vitamin D level prior to kidney transplantation between January 2011 and December 2013. Vitamin D deficiency was defined as the serum 25-(OH) vitamin D level less than 20 ng/mL. We examined the incidence of various posttransplant infections during follow up period. Factors that increased risk of infections were investigated with multiple logistic regression. Results: A total of 164 KTRs were followed up for mean 24.8 10.7 months. Among them, 135 (82.3%) patients had vitamin D deficiency. Patients with vitamin D deficiency showed significantly higher incidence of urinary tract infection (p=0.005) and any bacterial infections (p=0.003) compared to those without vitamin D deficiency. However, vitamin D deficiency was not associated with viral and fungal infections. Multivariate regression analysis revealed that vitamin D deficiency (odd ratio [OR] 21.5, 95% confidence interval [CI] 2.40 91.60, p=0.006) and desensitization prior to kidney transplantation (OR 5.58, 95% CI 1.69 8.45, p=0.005) were independent risk factors for post-transplant bacterial infections. Conclusion: Pre-transplant Vitamin D deficiency was significant risk factor for bacterial infections after kidney transplantation. Further studies will be needed to ascertain the preventive role of vitamin D supplementation.
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