대한신장학회

논문분류	춘계학술대회 초록집
제목	Characteristics and Outcomes of Living Kidney Donors
저자	Hye Jin Lim1, Swong Sik Kang1, Tai Yeon Koo1, Jong Cheol Jeong2, Curie Ahn3, Jaeseok Yang1
출판정보	2015; 2015(1):
키워드	생체신이식,공여자,신기능
초록	Objectives: We investigated trend of ECLD and long-term impact of kidney donation on renal function, proteinuria, and hypertension as well as in-hospital mortality, and in-hospital occurrence of end stage renal disease (ESRD). Methods: We retrospectively analyzed medical records of 1,075 living kidney donors at Seoul National University Hospital from 1993 through 2014. ECLD was defined to be one with at least 1 of 5 criteria as followings: age older than 60 years, body mass index >30 kg/m2, history of hypertension, estimated glomerular filtration rate (eGFR) <80 mL/min, and proteinuria or microscopic hematuria. Results: The mean age of donors was 41.6±10.9 years, and there were 567 (52.7%) female donors. The serum creatinine at donation was 0.8±0.2 mg/dL. The mean systolic and diastolic blood pressure was 120.3±12.7 and 75.9±9.8 mmHg at donation. A total of 469 (43.6%) donors met the ECLD criteria, and proportion of ECLD has been increasing (10.7% in 1993-1999, 20.7% in 2000-2004, 68.7% in 2005-2014). The proportions of each medical abnormality of ECLD were as followings: old age (4.1%), obesity (3.0%), hypertension (3.4%), low eGFR (63.7%), proteinuria (0.4%), and microscopic hematuria (2.6%). There was no difference in renal graft survival rate between ECLD and standard-criteria living donor groups. No donor was reported to need dialysis or transplantation during follow-up with median duration of 4.96 years. Five donors died at median of 10 years after donation. However, donor follow-up loss rate was 47.2% at 5 years, and 66.5% at 10 years. Renal function (eGFR) decreased during the first 1 year and was stabilized after then. At 3-year follow-up, 44.2% and 3.0% had CKD IIIa and IIIb, respectively. Urine protein-creatinine ratio (UPCR) was higher than 0.3 in 21 (2.0%) and UPCR was not higher than 1.0 in any donor at 3 years after donation. Hypertension was detected in 8.4% of donors at 3 years after donation. Conclusions: Most donors had a preserved renal function without significant proteinuria. Both mortality and progression to ESRD was very rare in carefully-selected kidney donors. However, we should follow up living donors more carefully, because follow-up loss rate was very high and ECLD is increasing.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정