대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	The Effects of Coenzyme Q10 in Sirolimus-Induced Pancreatic Islet Injury
저자	In O Sun1, Dong Won Lee2, Jin Long2, Jin Jian2, Sun Woo Lim2, Byung Ha Chung2, Chul Woo Yang2
출판정보	2015; 2015(1):
키워드	코엔자임,시로리무스,췌장
초록	Background: This study was performed to investigate whether coenzyme Q10 (CoQ10) has a protective effect in an experimental mouse model of sirolimus-induced pancreatic injury. Methods: Male Sprague-Dawley rats fed a low-salt diet were divided in five groups: group 1 (control, n=9), group 2 (SRL; sirolimus group, n=9), group 3 (SRL+ CoQ10; sirolimus treated by coenzyme Q10, n=9), group 4 (SRL+MET; sirolimus treated by metformin, n=9) and group 5 (SRL+MET+CoQ10; sirolimus treated by metformin and coenzyme Q10, n=9). Sirolimus-induced pancreatic injury in rats was induced with daily treatment of rapamycin (0.3 mg/kg, s.c.) for 28 days, and CoQ10 (20 mg/kg, p.o.) or metformin (250mg/kg, p.o.) was treatment alone or combination for 14 days. The effect of metformin and CoQ10 on rapamycin-induced pancreatic injury was evaluated by assessing intraperitoneal glucose tolerance test (IPGTT), plasma insulin concentration and the homeostatic model assessment of insulin resistance (HOMA-IR) index. An IPGTT was performed at the end of the 4 week treatment period, and the area under the curve of glucose (AUCg) was calculated by trapezoidal estimation from the values obtained in the IPGTT. Results: Four weeks of rapamycin treatment increased blood glucose levels and the HOMA-IR. Calculated AUCg was lower in SRL+MET group and SRL+MET+CoQ10 group than in SRL group (414 vs 314 vs 289 mg/dl min, p<0.05). However, Calculated AUCg did not differ significantly between the SRL group and CoQ10 group (414 vs 381 mg/dl min, p>0.05). Comparing HOMA-IR between SRL+MET group and SRL+MET+CoQ10 group, the value of SRL+MET+CoQ10 group was lower than that of SRL+MET group (0.53 vs 0.59, p>0.05). Conclusion: Co-administration of CoQ10 and metformin seems to have more beneficial effect against rapamycin-induced pancreatic injury than metformin single therapy.
원문(PDF)	PDF 원문보기

목록

위로가기