대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	The Effects of Thyroid Function on Clinical Outcomes after Kidney Transplantation
저자	Jung Nam An1, Jin Ho Hwang3, Sunhwa Lee2, Sejoong Kim4, Young Hoon Kim5, Yun Kyu Oh1, Duck-Jong Han5, Su-Kil Park6, Chun Soo Lim1, Curie Ahn7, Yon Su Kim2, Jung Pyo Lee1
출판정보	2015; 2015(1):
키워드	신장이식,갑상선 기능,임상적 예후
초록	Introduction: The abnormalities in thyroid function, especially triiodothyronine (T3) levels, are observed in patients with chronic kidney disease and end stage renal disease. Few previous studies evaluated the correlation between thyroid function after kidney transplantation and various clinical outcomes, in particular, in Asian patients. Methods: During the period of January 1997 to January 2012, the data about a total of 400 kidney transplant recipients who had thyroid function test measured within 5 years after kidney transplantation was analyzed through the retrospective review of electronic medical records of two medical centers. Results: Posttransplant thyroid-stimulating hormone (TSH) level was 1.9±4.2 μIU/mL, free thyroxin (fT4) level was 1.3±0.4 ng/dL, and T3 level was 112.4±34.1 ng/dL. After follow up duration of 77.3±53.0 months, 41 patients (10.3%) were diagnosed allograft failure. In Cox-regression analysis model, posttransplant T3 level was negatively correlated with graft failure (HR 0.98; 95% CI 0.97-0.99; p=0.001), however, post-transplant TSH and fT4 level were not associated. Divided to tertiles of T3 level, the risk for development of graft failure was the highest in the lowest group of T3 level (HR 6.25; 95% CI 1.74-22.44; p=0.005). After adjusting other risk factors for graft failure, posttransplant T3 level was also significantly associated with kidney allograft failure. In Kaplan-Meier curves, in patients with lower T3 level had the higher risk for allograft failure (Log Rank p=0.002). Conclusions: Triiodothyronine level measured after kidney transplantation is an independent risk factor for allograft failure. Regular measurement and monitoring of thyroid function should be the critical focus of post-transplant care.
원문(PDF)	PDF 원문보기

목록

위로가기