대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	IL-33 Enhances Host Tolerance to Candida Albicans Kidney Infections Through Induction of IL-13 Production by CD4+ T Cells
저자	Hyun Chul Chung1, Kyung Sun Park3, Hye J. Kim2, Jongha Park1, Byungsuk Kwon2, Jong Soo Lee1
출판정보	2015; 2015(1):
키워드	IL-33,감염 내성,면역 관용
초록	Susceptibility to systemic Candida albicans infection is determined not only by immune resistance but also by the ability to control Candida-induced immunopathologies. We previously showed that exogenous IL-33 can increase resistance to peritoneal C. albicans infection by regulating multiple steps of the neutrophil anti-Candida response. Here, using a mouse model of systemic candidiasis, we observed that IL-33 administration limited fungal burden and inflammation and increased survival. In kidneys, IL-33 seemed to directly act on neutrophils and CD4+ T cells: IL-33 administration enhanced fungal clearance by increasing neutrophil phagocytic activity without which Candida proliferation was uncontrollable. On the other hand, IL-33 stimulated CD4+ T cells to produce IL-13, and it in turn drove the polarization of macrophages toward the M2 type. Furthermore, the absence of IL-13 abolished IL-33-mediated polarization of M2 macrophages and renal functional recovery. In addition, IL-33 and IL-13 acted synergistically to increase M2 macrophage polarization and its phagocytic activity. Overall, this study identifies IL-33 as a cytokine that is able to induce resistance and tolerance, and suggests that targeting resistance and tolerance simultaneously with therapeutic IL-33 may benefit patients with systemic candidiasis.
원문(PDF)	PDF 원문보기

목록

위로가기