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논문분류	춘계학술대회 초록집
제목	Association between Dialysate Calcium Concentration and Infection-related Hospitalization in Incipient Hemodialysis Patients
저자	Tae Hyun Ban1, Su-Hyun Kim2, Young Ok Kim1, Dong Chan Jin1, Ho Chul Song1, Euy Jin Choi1, Yong-Lim Kim3, Yon-Su Kim4, Shin-Wook Kang5, Nam-Ho Kim6, Chul Woo Yang1, Yong Kyun Kim1
출판정보	2015; 2015(1):
키워드	투석액,칼슘,감염
초록	Background: Dialysate calcium concentration has been reported to have influence on cardiovascular disease and bone metabolism in hemodialysis (HD) patietns. Previous study showed that dialysate calcium concentration is closely associated with systemic inflmmation. It is unclear wheather dialysate calcium concentration is associated with infection- related clinical outcomes. In this study, we investigated the association between dialysate calcium concentration and infection-related hospitalization in incident HD patients. Methods: A total of 1182 incident HD patients were enrolled from the Clinical Research Center registry for End Stage Renal Disease, a multicenter prospective cohort study in Korea. Patients were classified into three groups according to dialysate calcium concentrations as high group (>3.5 mEq/L, n=182), standard group (3.0 mEq/L, n=701) and low group (<2.6 mEq/L, n=299). The primary outcome was infection-related hospitalization. Result: The median follow-up period was 16 months. Kaplan-Meier analysis showed that the infection related hospitalization rate was significantly higher in patients with high dialysate calcium (p=0.018, Log-rank). In the multivariate Cox regression analyses,group with high dialysate calcium concentration had a significantly higher risk of infection related-hospitalization compared with group withmid dialysate calcium concentration (HR 1.88, 95% CI, 1.11-3.17, p=0.019) and group with low dialysate calcium concentration (HR 2.79, 95% CI, 1.42-5.46, p=0.003). There was no significant difference in mortality between groups with the mid and low dialysate calcium concentration (HR 0.67, 95% CI, 0.37-1.22, p=0.189) after adjustment for clinical variables. Conclusions: High dialysate calcium concentration in hemodialysis is associated with significantly higher risk of infection-related hospitalization.
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