대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Usefullness of P11 in the Peripheral Blood as Depression Marker in Dialysis Patients
저자	Sihyung Park, Ga Hee Lee, Bong Soo Park, Kyubok Jin, Tae Hoon No, Jung Sun Kang, Yu Sun Jeon, Yang Wook Kim
출판정보	2015; 2015(1):
키워드	우울증,P11,투석
초록	Introduction: Patients on maintenance dialysis have the high prevalence of depression than normal population. The serotonin (5-hydroxytryptamine (5-HT)) system has been implicated in the pathophysiology of depression, especially, 5-HT receptors (5-HTRs) play an important role in regulating serotonin neurotransmission. P11 (a member of the S100 family of proteins) was found to interact with 5-HT1BR and 5-HT4R and have relation to depression in recent studies. Also, inflammation can affect the level of P11. We planned the study to assess the P11 as a depression marker in maintenance dialysis patients. Methods: As a single center cross-sectional study, we examined the peripheral blood mononuclear cells P11 mRNA, IL-6, TNF-α of patients with hemodialysis (HD, N=27), peritoneal dialysis (PD, N=39) and healthy group (N=7). Groups were divided by presence of depressive mood and categorized by severity of depressed mood via Beck Depression Inventory (BDI). Results: In non-depressive group (BDI <10), The dCt means of P11 were high in HD group (5.51±0.7 (HD, N=15) vs. 1.39±0.33 (PD, N=11) and 2.29±0.37 (control, N=7), p<0.05). The mean IL-6 levels were low in control group (6.43±1.34 pg/mL (HD) and 7.53±1.39 pg/mL (PD) vs. 2.23±0.49 pg/mL (control), p<0.05). The mean TNF-α levels were low in control group (4.31±0.26 pg/mL (HD) and 4.15±0.25 pg/mL (PD) vs. 1.85±0.53 pg/mL (control), p<0.05) respectively. In depressive group (BDI ≥10), P11 levels showed relationships with depression severity in peritoneal dialysis group (spearman rho=0.2, p=0.09). Conclusions: Systemic inflammation was observed in both dialysis groups. Despite taking into consideration the effect of inflammation, P11 could be used as depression marker in peritoneal dialysis group compared to control group. However, there was no significant correlation or tendency with P11 and depression in hemodialysis group. So, additional large studies and further investigations must be needed for clinical use.
원문(PDF)	PDF 원문보기

목록

위로가기