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논문분류	춘계학술대회 초록집
제목	NecroX-7, necroptosis inhibitor, attenuates cisplatin nephropathy
저자	Jin Young Jeong* 1, Dae Eun Choi1, Young Rok Ham1, Ki Ryang Na1, Kang Wook Lee1
출판정보	2016; 2016(1):
키워드	cisplatin nephrotoxicity, necrosis, Oxidative stress
초록	Background: Reactive oxygen species (ROS) generation, apoptosis, and necrosis play a role in cisplatin induced nephrotoxicity. LG life sciences developed a novel class of small molecule mitochondrial ROS scavenger NecroX series that can reduce reactive oxygen species and necroptosis pathway. We therefore investigated the effect of NecroX-7 on cisplatin nephrotoxicity in mice. Methods: C57BL/6 mice were divided into 4 groups; normal control group (n=5), NecroX-7 treated control group (n=5), vehicle with cisplatin (15mg/kg, intraperitoneal injection) treated group (n=9), and NecroX-7 (2mg/kg, intraperitoneal injection) with cisplatin treated group (n=9). We measured BUN and serum creatinine. We examined 8-OH deoxyguanosine, RIP1, RIP3, MLKL, and light microscopic findings (H&E and PAS stain). Results: C57BL/6 mice were divided into 4 groups; normal control group (n=5), NecroX-7 treated control group (n=5), vehicle with cisplatin (15mg/kg, intraperitoneal injection) treated group (n=9), and NecroX-7 (2mg/kg, intraperitoneal injection) with cisplatin treated group (n=9). We measured BUN and serum creatinine. We examined 8-OH deoxyguanosine, RIP1, RIP3, MLKL, and light microscopic findings (H&E and PAS stain). Conclusion: NecroX-7 attenuates cisplatin induced nephrotoxicity.
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