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논문분류	춘계학술대회 초록집
제목	Rhabdomyolysis associated with single-dose intravenous esomeprazole administration
저자	Ha Nee Chang*, Min Jeong Kim1, Dae-Hong Jeon1, Tae Won Lee1, Yire Kim1, Eun Jin Bae2, Hyun Seop Cho1, Hyun-Jung Kim1, Dong Jun Park2, 3, Se-Ho Chang1, 3
출판정보	2016; 2016(1):
키워드	acute kidney injury, proton pump inhibitor, rhabdomyolysis
초록	Background: Proton pump inhibitors (PPIs) are usually safe although serious adverse effects can occur. However, there were no reports of rhabdomyolysis associated with single-dose intravenous esomeprozole administration Methods: We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration. Results: A 45-year-old Korean male visited our emergency room because of persistent lower chest discomfort that started 10 h before. He had been diagnosed with diabetes and coronary heart disease, but discontinued oral hypoglycemic agents 1 month earlier. He continued to take medications for coronary heart disease. There was no abnormality on an electrocardiogram or in cardiac enzymes. Initial laboratory findings did not show abnormalities for muscle enzymes. Esomeprozole 40 mg was administrated intravenously for the control of his ambiguous chest discomfort. Then, 12 h later, he complained of abrupt severe right buttock pain. An area of tender muscle swelling 8 cm in diameter was seen on his right buttock area. Creatine kinase and lactate dehydrogenase were elevated, to 40,538 U/L and 1,326 U/L, respectively. A bone scan using 20 mCi of 99mTc- hydroxymethylene diphosphonate (HDP) was compatible with rhabdomyolysis. His muscular symptoms, signs, and laboratory findings improved markedly with conservative management, including hydration and urine alkalinization. He is being followed in the outpatient department with no evidence of recurrence. Conclusion: We should keep in mind that single-dose intravenous administration of esomeprazole can induce rhabdomyolysis Table: N/A
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