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논문분류	춘계학술대회 초록집
제목	EFFECT OF OMEGA 3 FATTY ACIDS ON STAMP2 EXPRESSION IN 5/6 NEPHRECTOMIZED RAT MODEL
저자	Su Mi Lee*, Hyo Jin Jeong1, Ji Young Lee1, Ki Tae Kim1, Young Ki Son1, Seong Eun Kim1, Won Suk An1
출판정보	2016; 2016(1):
키워드	chronic kidney disease, inflammation, omega 3 fatty acid, STAMP2
초록	Background: Six transmembrane protein of prostate 2 (STAMP2) is known as critical modulator of inflammation and metabolism in adipose tissue. There is no data about the expression of STAMP2 in chronic kidney disease which is inflammatory status and related with metabolic disorder. This study aimed to investigate the STAMP2 expression of heart and kidney in 5/6 nephrectomy (Nx) rats. In addition, we evaluated the effect of omega-3 fatty acid (FA) and vitamin D which are related with inflammation and metabolic disorder on STAMP2 expression. Methods: Sprague Dawley rats were divided into four groups: sham control (0.9% saline), 5/6 Nx (0.9% saline), 5/6 Nx treated with omega-3 FA (300 mg/kg/day by gastric gavage) group, 5/6 Nx treated with vitamin D (cholecalciferol 3000 IU/kg/week) and omega-3 FA groups. The expression of IκB, NF-κB, AMPK, SREBP1, Nox4, LXRab and STAMP2 were examined by western blot analysis. Results: Blood urea nitrogen and creatinine were the lowest in 5/6 Nx treated with omega-3 FA and vitamin D group among 5/6 Nx rat model. Compared with control, there was significant up-regulation of NF-κB, IκB, SREBP1, Nox4, and LXRab expression and a down-regulation of STAMP2 and phosphorylated AMPK expression in kidney and heart on 5/6 Nx model. We found that omega-3 FA prevented these up and down regulations related with inflammation and metabolic disorder of lipid. The STAMP2 expression was significantly up-regulated by omega-3 FA supplementation in both kidney and heart. In particular, STAMP2 expression was much more up-regulated in 5/6 Nx rats treated with omega-3 FA and vitamin D. Conclusion: The STAMP2 suppression of heart and kidney was found in 5/6 nephrectomy (Nx) rats. STAMP-2 activation induced by omega-3 FA supplementation may be one of potential mechanisms attenuating inflammation and metabolic disorder.
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