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논문분류	춘계학술대회 초록집
제목	Changes in the ratio of the maximum rate of tubular phosphate reabsorption to the glomerular filtration rate, and the 25-hydroxyvitamin D level after cholecalciferol administration in CKD patients
저자	Jieun Kim*, Young Joo Kwon1
출판정보	2016; 2016(1):
키워드	25-hydroxyvitamin D, cholecalciferol, CKD, tubular phosphate reabsorption
초록	Background: Adequate regulation of phosphorus in chronic kidney disease (CKD) is considered important because of its association with bone mineral metabolism. The present study aimed to determine the effects of cholecalciferol administration in patients with CKD by investigating the relationship between the serum calcidiol (25(OH)D3) level and the change in the renal phosphate reabsorption threshold. The relationship was assessed using the ratio of the maximum rate of tubular phosphate reabsorption to the glomerular filtration rate (TmP/GFR), which can be calculated with the levels of serum, urine phosphate, and creatinine. Methods: The study included 116 patients with predialysis stage 1–5 CKD who received cholecalciferol. In all patients, the phosphate, creatinine, calcium, intact parathyroid hormone, and 25(OH)D3 levels were measured 1 year before and after cholecalciferol administration. The TmP/GFR ratio was calculated using a simple algorithm. Results: There was no correlation between the TmP/GFR ratio and the 25(OH)D3 level in the patients. In subgroup analysis, patients with a decline in the TmP/GFR ratio from 1 year previously to the time of administration showed a positive correlation between ΔTmP/GFR and Δ25(OH)D3 after cholecalciferol administration (p = 0.044). Conclusion: Cholecalciferol administration might increase the TmP/GFR ratio and 25(OH)D3 level in CKD patients with deterioration of bone mineral metabolism. Additionally, 25(OH)D3 may be beneficial for the progression of mineral metabolism, as it can alter the TmP/GFR ratio. Figures:
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