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논문분류	춘계학술대회 초록집
제목	Genome-wide association analysis identifies multiple loci associated with kidney function-related traits in Korean populations
저자	Nam Ju Heo* 1, Young Lee1
출판정보	2016; 2016(1):
키워드	chronic kidney disease, Genome-wide association analysis , uric acid
초록	Background: Chronic kidney disease (CKD) is a significant public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report an analysis of genome-wide association studies for kidney function–related traits, including 7,468 Korean individuals from SNUH HCS Gangnam Center cohort. Methods: Here, we report an analysis of genome-wide association studies for kidney function–related traits, including 7,468 Korean individuals from SNUH HCS Gangnam Center cohort. Results: Our analysis identified loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels in Korean. We further examined these loci with in replication in individuals of the same SNUH HCS Gangnam Center cohort including 746 individuals. Conclusion: We identify associations among these loci with kidney function–related traits. These findings provide new insights into the susceptibility to CKD and genetics of kidney function.
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