대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Clinical Utility of Random Spot Urine Protein to Creatinine Ratio Modified by Estimated Daily Creatinine Excretion in Children
저자	Eunmi Yang* 1, Chan Jong Kim1
출판정보	2016; 2016(1):
키워드	24-hour urine protein, Proteinuria, Spot urine protein-to-creatinine ratio
초록	Background: The spot urine protein to creatinine ratio (UPCR) has been widely used in predicting a 24-hour urine protein excretion. Patients with low daily urine creatinine excretion might lead to overestimation of the 24-hour urine protein by UPCR. The aim of this study was to predict the 24-hour urine protein using UPCR adjusted by estimated urinary creatinine excretion rate (UCr) in children. Methods: This study included 443 children whose 24-hour urine protein and random UPCR were measured concomitantly. Estimated 24-hour creatinine excretion was calculated by three previously existing equations. One equation for adult (Cockcroft-Gault formula) and two equations for children (Ghazali-Barratt and Hellerstein equation) were used. Correlation was accessed between estimated UCr and measured UCr. We estimated the 24-hour urine protein excretion from measured the UPCR by multiplying the estimated UCr. Results were compared with a 24-hour urine protein excretion. Results: The patients’ mean age was 9 years, 46% were male. A strong correlation was found between a measured UCr and estimated UCr, especially, in the equation of Cockcroft (r = 0.845, P < 0.001). Cockcroft equation showed less bias (mean difference [measured-estimated UCr] 5.8%) and moderate precision (estimated UCr within 30% of measured UCr among 81%). There were strong correlation between UPCR and 24-hour urine protein (r = 0.812, P < 0.001), and correlation was improved after multiplying the UPCR by the estimated UCr (r = 0.855, P < 0.001). The percentages of UPCR multiplying by estimated UCr within 15% and 30% of 24hr urine protein excretion were 23% and 47%, respectively. Conclusion: The spot UPCR multiplying by the estimated UCr can improve the accuracy of prediction of estimating 24-hour urine protein in children.
원문(PDF)	PDF 원문보기

목록

위로가기