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논문분류	춘계학술대회 초록집
제목	Association between 25-hydroxyvitamin D deficiency and rapid chronic kidney disease progression
저자	Ha Yeon Kim*, Eun Hui Bae1, Seong Kwon Ma1, Kook-Hwan Oh2, Curie Ahn2, Soo Wan Kim1
출판정보	2016; 2016(1):
키워드	25-hydroxyvitamin D deficiency, chronic kidney disease, rapid eGFR decline
초록	Background: 25-hydroxyvitamin D [25(OH)D] deficiency is highly prevalent in the chronic kidney disease (CKD) population, which is linked with cardiovascular events and mortality. Here we evaluated the relationship between 25(OH)D deficiency and the rapid declining in estimated glomerular filtration rate (eGFR) using KNOW-CKD cohort data. Methods: In total, 1063 CKD patients were measured for the concentrations of 25(OH)D and creatinine with a follow-up of 4 years in a prospective multi-center cohort study of CKD patients in Korea. We divided the patients into two groups according to their serum 25(OH)D levels (deficiency group: 25(OH)D < 15 ng/ml, vs. non-deficiency group: 25(OH)D ≥ 15 ng/ml). Rapid progression was defined by the decline of eGFR over 5 ml/min/1.73m2 per year (N=326) and as controls if decline of eGFR was under 1 ml/min/1.73m2 per year (N=609). Results: The average of decline in eGFR was 1.82 ml/min/1.73m2 per year, maximum value of which was 53.8 ml/min/1.73m2 per year. The mean of 25(OH)D was 16.8 ng/ml in the rapid progression groups, while that of the control group was 18.5 ng/ml. Univariate linear regression analysis showed that the rapid CKD decline was correlated with age, diabetes, serum albumin, 25(OH)D deficiency, cystatin C, and the albumin-to-creatinine ratio. Multiple analysis revealed that age, hypoalbuminemia, 25(OH)D deficiency, diabetes, and macroalbuminuria associated with rapid progression. Conclusion: Vitamin D deficiency was associated with rapid eGFR decline in CKD patients. The results of this prospective cohort study suggest that vitamin D supplementation may significantly help the preservation of renal function in CKD patients.
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