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논문분류	춘계학술대회 초록집
제목	The Effect of Lercanidipine added to renin-angiotensin-aldosterone blockade on proteinuria excretion rate and renal function in patients with non-diabetic chronic kidney disease
저자	Hyung Jong Kim* 1, Sang Ho Lee2, Kyu-Bok Choi3, Kyu Hun Choi4
출판정보	2016; 2016(1):
키워드	calcium channel blocker, Proteinuria, renin angiotensin system
초록	Background: Lercanidipine is a dihydropiridine calcium antagonist iwth high lipophilicity and high vascular electivity. Calcium channel blocker may be have the renoprotective effect but it's effect is a controversial issue. Calcium channel blocker could improve renal function in patinets previous treated with aniotensin-converting inhibitors. We investigated that The effectiveness of lercanidipine in patients with non-diabetic chronic kidney disease. Methods: A total of 54 hypertensive chronic kidney disease patients from 3 korean center was recruited. All patients were receiving treatment with either angiotension converting inhibitor or angiotension receptor blocker and have chronic renal faliure stage 2, 3, 4 (15mL/min ≤ eGFR ≤ 90mL/min). Antihypertensive therapy with the lercanidipine at a dose of 10 ~ 20mg once a day was given to all patients. Serum creatinine and proteinuria had to measured at every visit. Blood samples were also analyzed for cholesterol, hsCRP, electrolyte, albumin. Results: Fourty eight patients was complete finishied for this study(age 49.24 ± 12.82 years, male 38%, female 62%). Blood pressure significantly decreased from 139.02 ± 8.94/86.70 ± 7.73mmHg to 122.86 ± 12.78/74.14 ± 7.04mmHg (p<0.05). Proteinuria excretion rate (random urine protein/creatinine ratio) significantly decreased from 1.94 ± 1.77 to 1.61 ± 1.52 (p<0.05). eGFR showed no significant difference. Conclusion: We investigated that Lercanidipine showed an improvement in proteinuria excretion rate and a good tolerbility in non-diabetic chronic kidney disease.
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