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논문분류	춘계학술대회 초록집
제목	Sarcopenia is associated with mortality in peritoneal dialysis patients
저자	Gyeongmin Jeong* 1, Yeon Hee Kim1, Seok Hui Kang1, Kyu Hyang Cho1, Jong Won Park1, Kyung Woo Yoon1, 1, Jun Young Do1
출판정보	2016; 2016(1):
키워드	all-cause mortality, dual-energy X-ray absorptiometry, peritoneal dialysis, sarcopenia
초록	Background: Few studies have demonstrated an association between sarcopenia and mortality in peritoneal dialysis (PD) patients. The aim of the present study was to evaluate the clinical association between sarcopenia and all-cause or cardiovascular mortalities in PD patients. Methods: We reviewed medical records collected at Yeungnam University Hospital, Korea, and identified all adults (> 18 years) who underwent PD between January 2001, and April 2014. Each appendicular lean mass (both upper and lower extremities) was measured using DXA. The sarcopenia index was calculated by dividing total appendicular lean mass (kg) by BMI (kg/m2). Results: A total of 631 patients were enrolled in the present study. The number of participants in the Normal and Sarcopenia groups was 328 and 303, respectively. Initial sarcopenia was positively associated with comorbidity index and inversely associated with RRF, edema index level, APD, and women. Cox regression analyses showed that hazard ratio (95% CI) in Sarcopenia group was 1.74 (1.35–2.24) in univariate (P < 0.001) and 1.71 (1.28–2.26) in multivariate (P < 0.001) compared with the Normal group. In addition, hazard ratio for 0.1 increase in sarcopenia index was 0.89 (0.84–0.95) in univariate (P = 0.001) and 0.84 (0.76–0.91) in multivariate (P < 0.001). Analyses using 1 year sarcopenia index showed similar trends with those from initial sarcopenia index. Conclusion: Sarcopenia was found to be associated with all-cause and cardiovascular mortalities in incident PD patients. Hence, the presence of sarcopenia should be closely monitored and prevention of sarcopenia may be necessary to improve the prognosis in PD patients.
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