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논문분류	춘계학술대회 초록집
제목	Spontaneous Seroconversion of Hepatitis B viral in long term Hemodialysis patient.
저자	Hye Jeong Cho* 1, Soo Hyung Park1, Hyung Jong Kim1
출판정보	2016; 2016(1):
키워드	Hemodialysis, hepatitis B, seroconversion
초록	ackground: Hemodialysis patients are at an increased risk of infection with hepatitis B virus(HBV). There are only a few reports of spontaneous HBsAg clesrance in hemosialysis patients with chronic HBV infection. We report a case of chronic HBV infection spontaneously seroconverted in hemodialysis patient with good natural killer cell activity. Methods: A 52-year-old woman was started on hemodialysis becasue of chronic kidney disease from diabetic nephropathy. she was found to be HBsAg positive and Anti-HBs Ab negative, Anti-HBc Ab positive. But liver transminases were normal. Results: Twelve years after she started hemodialysis, her HBsAg was reported negative. Anti-HBc Ab was positive, HBeAg was negtive, anti-HBe Ab was positive, and anti-HBs Ab remained negative. Also, HBV DNA PCR was not detectedd. After two years, her anti-HBs titer became positive at 44.43 IU. Her natural killer cell activity was > 2000 pg/mL (reference range > 200pg/mL). Conclusion: Seroconversion of chronic HBV surface antigenemia and the development of anti-HBs antibody are a rare event in hemodialysis patients. We thought that a good immune activity like as increased Natural killer cell activity can improve the response to treatment to help clear HBsAg in chronic carriers in hemodalysis patients.
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