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논문분류	춘계학술대회 초록집
제목	Involvement of microtubule dynamics on the process of regeneration after kidney ischemia/reperfusion injury
저자	Sangjun Han*, Hong Seok Choi, Jee In Kim, Kwon Moo Park
출판정보	2016; 2016(1):
키워드	cell cycle arrest, fibrosis, ischemia reperfusion, microtubule
초록	Background: The microtubule network is closely associated with many diseases. However, the role of microtubule dynamics on kidney diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) have yet to be understood. Methods: In this study, we investigated an involvement of microtubule dynamics in injury and repair after ischemia/reperfusion (I/R) insult in c57/bl6 mice. Results: I/R in the kidney induced deacetylation of the microtubules with a decrease in α-tubulin acetyltransferase 1 (α-TAT1). Paclitaxel (taxol), an inhibitor of deacetylation of microtubule, treatment retarded tubular cell proliferation, resulting in delayed renal functional recovery and accelerated fibrosis. Conclusion: This study suggests that the regulation of microtubule dynamics is important to control the processes of repair from AKI, and subsequent progression to CKD.
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