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논문분류	춘계학술대회 초록집
제목	THERAPEUTIC ACTIVITY OF HISTONE DEACETYLASE INHIBITOR SB939 ON RENAL FIBROSIS
저자	Sun-Woo Kang*, Taehee Kim1, Yeong-Hoon Kim1, Su-Kil Seo1
출판정보	2016; 2016(1):
키워드	HDAC, RENAL FIBROSIS, SB939, EMT, UUO
초록	Background: Fibrosis is the final, common pathological outcome of many chronic kidney diseases. Although histone deacetylases (HDACs) have been reported to be involved in renal fibrosis, revealed HDAC inhibitor for the disease are not satisfactory. Therefore, more relevant HDAC inhibitors for renal fibrosis are needed to find. We initially found that none-cytotoxic concentration of SB939 (pracinostat) had strong anti-fibrotic activity involved in drastically decreasing TGF-SMA and fibronectin on renal fibroblast cell line NRK. In comparison with other inhibitors, the efficacy of SB939 was higher than TSA and MS275 which both have been reported to have anti-renal fibrotic effect. Similar anti-fibrotic activity of SB939 was confirmed on epithelial-to-mesenchymal transition (EMT) using human renal proximal tubular epithelial cell line HK-2. Methods: To evaluate in vivo activity, we administrated SB939 into unilateral ureteric obstruction (UUO) model. Results: SB939 treatment markedly inhibited tissue injury and accumulation of alpha-SMA. Cytokines associated with fibrosis were also significantly decreased by SB939 treatment Conclusion: Our results demonstrate that SB939 has therapeutic potential for inhibition of renal fibrosis.
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