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논문분류	춘계학술대회 초록집
제목	AICAR, AMPK activator, protects cisplatin-induced acute kidney injury
저자	Bodokhsuren Tsogbadrakh* 1, Kyung Don Ju1, Hyo Jin Kim2, Jinho Lee, Kook-Hwan Oh1, Curie Ahn1
출판정보	2016; 2016(1):
키워드	None
초록	Background: Cisplatin causes acute kidney injury (AKI) through proximal tubular injury. We investigated protective effect of the adenosine monophosphate protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) against cisplatin induced AKI. Methods: Male Sprague-Dawley rats were randomly divided into four groups: control, AICAR, cisplatin and cisplatin + AICAR. SD rats were injected with single dose of cisplatin (7 mg/kg, i.p.). AICAR was administered to rats at 100mg/kg i.p. daily for 5 days. The kidneys were harvested on the day 5. Blood urea nitrogen (BUN) and the serum creatinine were measured. Renal damage was analyzed in sections stained with Hemotoxylin and Eosin (H&E). Results: A single injection of cisplatin caused marked increase of the serum creatinine and BUN levels on day 5. BUN and serum creatinine levels decreased in cisplatin-treated rats after treatment with AICAR. Compared to cisplatin group, acute tubular necrosis score decreased in rat treated with cisplatin + AICAR. Conclusion: This study suggests that activation of AMPK activator AICAR might ameliorate the cisplatin induced AKI, partially by inhibition of the proximal tubular injury. We will continue to evaluate for JAK/STAT/SOCS pathway or RAS/MAPK signaling pathway.
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