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논문분류	춘계학술대회 초록집
제목	Identification of early Biomarkers for Acute Kidney Injury Following Self Poisoning with Combined Washing Powder (Mixture of Potassium permanganate and Oxalic acid) in Sri Lanka
저자	Thilini Wijerathna* 1, 2, Indika Gawarammana1, 3, Dhammika Dissanayaka2, Nick Buckeley4
출판정보	2016; 2016(1):
키워드	acute kidney injury, biomarker, Oxalic acid, Potassium permanganate
초록	Background: In Sri Lanka, kidney injury (AKI) is a common clinical manifestation following self poisoning with combined washing powder (CWP) containing potassium permanganate (KMnO4) and oxalic acid (H2C2O4). We hypothesized that a panel of novel urinary biomarkers is superior to serum creatinine (sCr) and attempted to determine whether increased levels are related to mechanisms specific injury pathways. Methods: Eighty five patients with CWP poisoning were recruited to the study. Kinetics of sCr [(based on acute kidney injury network criteria (AKIN)] and serum sCysC were compared and urinary biomarker levels were measured every 8 hours untill day 1 and then daily until discharge. Results: Seventy four percent developed AKI while of that, 70% developed severe AKI (AKIN2/3). Grouping of patients based on sCr and serum cystatin C (sCysC) criteria was not significantly different. Percentage increment of sCr (>150%) from baseline was higher than sCys (<50%) at 24 hours post-ingestion. Urinary markers (Albumin, KIM – 1 and clusterin) demonstrated excellent to moderate diagnostic performance (AUC-ROC: Albumin 0.98, clusterin 0.86, KIM – 1 0.83) at Cmax24 (maximum biomarker concentration obtained during 24 hours). Conclusion: Urinary albumin, clusterin and KIM – 1 diagnosed AKI following self poisoning with CWP.
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